Delta-8 THC is one of the many cannabinoids in cannabis. Delta-8 THC is a saturated 8 carbon atom and it has a similar effect to delta 9 THC, but with a slightly different duration and intensity.
Delta 8 bundles or Delta(8)-Tetrahydrocannabinol was first isolated and identified by two independent groups in 1970, Raphael Mechoulam’s research group at the Weizmann Institute of Science, Israel and Dr Edda Segall’s team at the University of Kansas . It can be found in both marijuana and hashish in small quantities.
Dr Edda Segall was doing research on the structure determination of D9THC (delta-9 tetrahydrocannabinol) and delta-8 THC to determine its constitutions and was able to determine and separate the two, discovering delta-8 THC in 1970 .
Delta 8 THC is a CB1 receptor agonist. Delta 8 THC has also been found to be an opioid CB1 receptor partial agonist, which suggests that it might have potential as an analgesic drug with limited abuse liability. The research done by DrMechoulam’s team concluded that delta-8 THC had no psychoactive properties, but more extensive tests revealed some interesting effects. Delta 8 THC has now become widely known for having analgesic effects, which are minimal due to the low levels of CB1 receptors present in the brain. However, delta-8 THC is thought to have some anti-tumor properties since it can block the enzyme needed for cancer cells to grow. Visit here https://www.exhalewell.com/delta-8-bundles/ and understand more.
Delta 8 THC binds more specifically to CB1 receptors than delta 9 THC and has a higher affinity for CB2 receptors. Delta 8 THC also acts as an antagonist of G protein-coupled inward rectifying potassium channels (GIRKs) on presynaptic terminals, which are involved in inhibitory neurotransmission. It inhibits GABA release from mouse cerebellar neurons by binding to alpha3beta4 nicotinic acetylcholine receptors on axon termini of GABAergic neurons of Aplysiacalifornica [9] . This suggests that other species might also have this type of receptor, which could help to explain why delta 8 THC has analgesic effects.
Delta-8 THC is used for medical research as the results are definitive and very reliable. Delta-8 THC is not listed in the controlled substances act or any individual state regulations because it does not cause a high like other cannabinoids do.
